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Effective Interventions

HIV Prevention that Works

What Is HIV Prevention that Works?
The mission of CDC’s Division of HIV/AIDS Prevention (DHAP) is to prevent HIV infection and reduce the incidence of HIV-related illness and death. To achieve this mission, DHAP is committed to the use of scalable, cost-effective interventions with demonstrated potential to reduce new infections in the right populations for high impact prevention.   

CDC’s Prevention Research Synthesis (PRS) Projectroutinely updates an online Compendium of Evidence-Based Interventions and Best Practices for HIV Prevention by adding newly identified evidence-based interventions (EBI) and best practices to significantly reduce HIV risk or promote HIV care. The Compendium comprises three chapters: a new chapter lists best practices for promoting linkage to, retention in, and re-engagement in HIV medical care; a chapter lists EBIs for promoting HIV medication adherence among persons with HIV ; and a chapter lists behavioral EBIs for reducing sex or drug injection behaviors directly impacting HIV transmission risk. 

What Is the Purpose of this Site?
This CDC-sponsored website is designed to support the HIV prevention workforce in the United States by providing resources and trainings informed by the best available science that can be used to implement HIV prevention interventions and strategies.  

The content on this site includes scientifically proven, cost-effective, and scalable interventions and best practices from the Compendium of Evidence-based Interventions and Best Practices for HIV Prevention. The site content is in alignment with the DHAP Strategic Plan 2017 – 2020. The Plan reflects DHAP’s response to new opportunities for HIV prevention created by critical shifts in prevention science as well as in the national, state, and local economic and policy environments.  

Who is the Audience?

The audience for this site is primarily U.S.-based HIV prevention providers in health departments, community-based organizations and healthcare organizations. Other geographic regions may find the content of this site suitable for adaptation to their populations.

What Information Is on this Site?

You will find resources for meeting the HIV prevention needs of both people with HIV and people who are HIV-negative. This site offers a searchable training calendar; online registration for classroom trainings; and online eLearning courses. You can access established and new materials to learn more about or support implementation of CDC-supported behavioral, biomedical, and structural-level interventions and public health strategies.

Where Can I Find Information on Interventions and Strategies Previously Supported by CDC?

In its ongoing effort to align HIV prevention resources with current surveillance data and the High-Impact HIV Prevention strategy, CDC's Division of HIV/AIDS Prevention (DHAP) no longer offers face-to-face training or capacity building assistance on a number of evidence-based interventions. The implementation materials for interventions previously supported by CDC have either been archived or removed from this site. 

The archived interventions are listed below. Archived implementation materials are still available and can be accessed using the links provided:

If you are looking for intervention materials that have been removed from this site, please email  Interventions that have been removed include: Adult Identity Mentoring (AIM); Comprehensive Risk Counseling and Services (CRCS); Focus on the Future (FOF); The Future is Ours (FIO); Healthy Love; Holistic Health Recovery Program (HHRP); Modelo de Intervención Psicomédica (MIP); Nia; Real AIDS Prevention Project (RAPP); RESPECT; Safety Counts; Salud, Educación, Prevención, y Autocuidado (SEPA); Street Smart; Together Learning Choices (TLC).


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